How much VRAM does Qwen 2.5 VL 72B need?

Qwen 2.5 VL 72B (72B parameters) requires approximately 64.0 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 VL 72B?

The recommended quantization for Qwen 2.5 VL 72B is Q4_K_M, which balances quality and memory efficiency.

Can it run?

Yes, AMD Instinct MI210 64GB can run Qwen 2.5 VL 72B with a C grade (Runs with offload). Expected decode speed: 26.9 tok/s.

CUsable

Runs with offload

Using Q4_K_M in vLLM

Capabilities:

Fit status

Runs with offload

Decode

26.9 tok/s

TTFT

7210 ms

Safe context

16K

Memory

64.0 GB / 64.0 GB

Weights43.9 GB

KV Cache11.3 GB

Runtime2.4 GB

Headroom6.4 GB

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	D	Very compromised (needs ~6.6 GB host RAM)	22.1 tok/s	12716 ms	27K
Chat	C	Tight fit	25.4 tok/s	4164 ms	9K
Coding	C	Runs with offload	26.9 tok/s	7210 ms	16K
RAG	D	Very compromised (needs ~6.6 GB host RAM)	22.1 tok/s	15895 ms	27K
Reasoning	C	Runs with offload	25.4 tok/s	9022 ms

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	D39
Q3_K_S	3	35.3 GB	Low	C41
NVFP4	4

Ollama

ollama run qwen-2.5-vl-72b

HuggingFace

huggingface-cli download qwen-2.5-vl-72b

Upgrade options

Mac Studio M2 Ultra 128GBBudget pick

C10.6 tok/s decode

~$3,999 MSRP

Mac Studio M1 Ultra 128GBBest value

C10 tok/s decode

~$3,999 MSRP

NVIDIA GH200 96GBBiggest leap