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All estimates are approximations based on mathematical models and public specifications. Actual performance may vary. Do not make purchasing decisions based solely on these estimates.

Data sourced from Hugging Face, Ollama, and official model documentation. Model names and logos are trademarks of their respective owners.

© 2026 Will It Run AI — Fase Consulting Ibiza, S.L. (NIF: B57969656)

Home/Qwen 2.5 72B/on AMD Instinct MI210 64GB

Can it run?

Can AMD Instinct MI210 64GB run Qwen 2.5 72B?

CUsable

Runs with offload

Using Q4_K_M in Ollama

Capabilities:

Fit status

Runs with offload

Decode

25.4 tok/s

TTFT

7634 ms

Safe context

16K

Memory

62.8 GB / 64.0 GB

Memory breakdown

Weights43.9 GB
KV Cache11.3 GB
Runtime1.2 GB
Headroom6.4 GB

Performance by workload

WorkloadGradeFitDecodeTTFTContext
Agentic CodingDVery compromised (needs ~5.9 GB host RAM)22.4 tok/s12548 ms28K
ChatCTight fit25.4 tok/s4164 ms9K
CodingCRuns with offload25.4 tok/s7634 ms16K
RAGDVery compromised (needs ~5.9 GB host RAM)22.4 tok/s15684 ms28K
ReasoningCRuns with offload25.4 tok/s9022 ms16K

Quantization options

How Qwen 2.5 72B (72B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).

QuantBitsVRAMQualityFit
Q2_K
2
28.1 GB
LowD39
Q3_K_S
3
35.3 GB
LowC41
NVFP4
4
40.3 GB
MediumC43
Q4_K_MBest for your GPU
4
43.9 GB
MediumC44
Q5_K_M
5
51.8 GB
HighC45
Q6_K
6
59.0 GB
HighC45
Q8_0
8
77.0 GB
Very HighF0
F16
16
147.6 GB
MaximumF0

Get started

Ollama
ollama run qwen-2.5-72b
HuggingFace
huggingface-cli download qwen-2.5-72b

Upgrade options

Hardware that runs Qwen 2.5 72B well

AppleMac Studio M2 Ultra 128GBBudget pick
C10.6 tok/s decode

~$3,999 MSRP

AppleMac Studio M1 Ultra 128GBBest value
C10 tok/s decode

~$3,999 MSRP

NVIDIANVIDIA GH200 96GBBiggest leap
B73.8 tok/s decode

 

AMDAMD Instinct MI300A 128GBAMD upgrade
C84.5 tok/s decode

 

See all results for AMD Instinct MI210 64GBSee all hardware for Qwen 2.5 72B