Question 1

Can Quadro RTX 8000 48GB run Qwen3-Coder 480B A35B Instruct?

Accepted Answer

No, Qwen3-Coder 480B A35B Instruct requires more memory than Quadro RTX 8000 48GB provides.

Question 2

How much VRAM does Qwen3-Coder 480B A35B Instruct need?

Accepted Answer

Qwen3-Coder 480B A35B Instruct (480B parameters) requires approximately 305.5 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3-Coder 480B A35B Instruct?

Accepted Answer

The recommended quantization for Qwen3-Coder 480B A35B Instruct is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	F	Too heavy	4.6 tok/s	61065 ms	5K
Chat	F	Too heavy	4.6 tok/s	22899 ms	4K
Coding	F	Too heavy	4.6 tok/s	41982 ms	4K
RAG	F	Too heavy	4.6 tok/s	76331 ms	5K
Reasoning	F	Too heavy	4.6 tok/s	49615 ms	4K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	187.2 GB	Low	F0
Q3_K_S	3	235.2 GB	Low	F0
NVFP4	4

Can Quadro RTX 8000 48GB run Qwen3-Coder 480B A35B Instruct?

Memory breakdown