Question 1

Can AMD Instinct MI350X 288GB run Qwen3-Coder 480B A35B Instruct?

Accepted Answer

Yes, AMD Instinct MI350X 288GB can run Qwen3-Coder 480B A35B Instruct with a C grade (Very compromised). Expected decode speed: 49.0 tok/s.

Question 2

How much VRAM does Qwen3-Coder 480B A35B Instruct need?

Accepted Answer

Qwen3-Coder 480B A35B Instruct (480B parameters) requires approximately 329.5 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3-Coder 480B A35B Instruct?

Accepted Answer

The recommended quantization for Qwen3-Coder 480B A35B Instruct is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Very compromised	48.4 tok/s	5823 ms	28K
Chat	C	Very compromised	49.4 tok/s	2139 ms	7K
Coding	C	Very compromised	49.0 tok/s	3949 ms	14K
RAG	C	Very compromised	48.4 tok/s	7279 ms	28K
Reasoning	C	Very compromised	49.0 tok/s	4667 ms	14K

Quant	Bits	VRAM	Quality	Fit
Q2_KBest for your GPU	2	187.2 GB	Low	C43
Q3_K_S	3	235.2 GB	Low	C45

Can AMD Instinct MI350X 288GB run Qwen3-Coder 480B A35B Instruct?

Memory breakdown