Question 1

Can AMD Instinct MI325X 256GB run Qwen3-Coder 480B A35B Instruct?

Accepted Answer

No, Qwen3-Coder 480B A35B Instruct requires more memory than AMD Instinct MI325X 256GB provides.

Question 2

How much VRAM does Qwen3-Coder 480B A35B Instruct need?

Accepted Answer

Qwen3-Coder 480B A35B Instruct (480B parameters) requires approximately 326.3 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3-Coder 480B A35B Instruct?

Accepted Answer

The recommended quantization for Qwen3-Coder 480B A35B Instruct is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	F	Too heavy	41.2 tok/s	6839 ms	25K
Chat	F	Too heavy	41.2 tok/s	2565 ms	6K
Coding	F	Too heavy	41.2 tok/s	4702 ms	13K
RAG	F	Too heavy	41.2 tok/s	8549 ms	25K
Reasoning	F	Too heavy	41.2 tok/s	5557 ms	13K

Quant	Bits	VRAM	Quality	Fit
Q2_KBest for your GPU	2	187.2 GB	Low	C45
Q3_K_S	3	235.2 GB	Low	C45

Can AMD Instinct MI325X 256GB run Qwen3-Coder 480B A35B Instruct?

Memory breakdown