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All estimates are approximations based on mathematical models and public specifications. Actual performance may vary. Do not make purchasing decisions based solely on these estimates.

Data sourced from Hugging Face, Ollama, and official model documentation. Model names and logos are trademarks of their respective owners.

© 2026 Will It Run AI — Fase Consulting Ibiza, S.L. (NIF: B57969656)

Home/Qwen3-Coder 480B A35B Instruct/on AMD Instinct MI300X 192GB

Can it run?

Can AMD Instinct MI300X 192GB run Qwen3-Coder 480B A35B Instruct?

FWon't run

Too heavy

Using Q4_K_M in vLLM

Capabilities:

Fit status

Too heavy

Decode

39.4 tok/s

TTFT

4914 ms

Safe context

10K

Memory

319.9 GB / 192.0 GB

Memory breakdown

Weights292.8 GB
KV Cache5.5 GB
Runtime2.4 GB
Headroom19.2 GB

Performance by workload

WorkloadGradeFitDecodeTTFTContext
Agentic CodingFToo heavy39.4 tok/s7147 ms19K
ChatFToo heavy39.4 tok/s2680 ms5K
CodingFToo heavy39.4 tok/s4914 ms10K
RAGFToo heavy39.4 tok/s8934 ms19K
ReasoningFToo heavy39.4 tok/s5807 ms10K

Quantization options

How Qwen3-Coder 480B A35B Instruct (480B params) fits at each quantization level on AMD Instinct MI300X 192GB (192.0 GB usable).

QuantBitsVRAMQualityFit
Q2_K
2
187.2 GB
LowC45
Q3_K_S
3
235.2 GB
LowF0
NVFP4
4
268.8 GB
MediumF0
Q4_K_M
4
292.8 GB
MediumF0
Q5_K_M
5
345.6 GB
HighF0
Q6_K
6
393.6 GB
HighF0
Q8_0
8
513.6 GB
Very HighF0
F16
16
984.0 GB
MaximumF0

Upgrade options

Hardware that runs Qwen3-Coder 480B A35B Instruct well

AMDAMD Instinct MI350X 288GBBest value
C49.7 tok/s decode

~$8,000 MSRP

See all results for AMD Instinct MI300X 192GBSee all hardware for Qwen3-Coder 480B A35B Instruct