Question 1

Can AMD Instinct MI350X 288GB run Qwen 3 235B A22B?

Accepted Answer

Yes, AMD Instinct MI350X 288GB can run Qwen 3 235B A22B with a B grade (Runs well). Expected decode speed: 107.2 tok/s.

Question 2

How much VRAM does Qwen 3 235B A22B need?

Accepted Answer

Qwen 3 235B A22B (235B parameters) requires approximately 176.5 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen 3 235B A22B?

Accepted Answer

The recommended quantization for Qwen 3 235B A22B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	B	Runs well	108.7 tok/s	2591 ms	51K
Chat	B	Runs well	108.7 tok/s	972 ms	13K
Coding	B	Runs well	107.2 tok/s	1806 ms	26K
RAG	B	Runs well	108.7 tok/s	3239 ms	51K
Reasoning	B	Runs well	108.7 tok/s	2105 ms	26K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	91.7 GB	Low	D36
Q3_K_S	3	115.2 GB	Low	D38
NVFP4	4

Can AMD Instinct MI350X 288GB run Qwen 3 235B A22B?

Memory breakdown