Question 1

Can AMD Instinct MI325X 256GB run Qwen 3 235B A22B?

Accepted Answer

Yes, AMD Instinct MI325X 256GB can run Qwen 3 235B A22B with a B grade (Runs well). Expected decode speed: 80.4 tok/s.

Question 2

How much VRAM does Qwen 3 235B A22B need?

Accepted Answer

Qwen 3 235B A22B (235B parameters) requires approximately 173.3 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen 3 235B A22B?

Accepted Answer

The recommended quantization for Qwen 3 235B A22B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	B	Runs well	81.5 tok/s	3455 ms	46K
Chat	B	Runs well	81.5 tok/s	1296 ms	12K
Coding	B	Runs well	80.4 tok/s	2408 ms	24K
RAG	B	Runs well	81.5 tok/s	4319 ms	46K
Reasoning	B	Runs well	80.4 tok/s	2846 ms	24K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	91.7 GB	Low	D37
Q3_K_S	3	115.2 GB	Low	D39
NVFP4	4

Can AMD Instinct MI325X 256GB run Qwen 3 235B A22B?

Memory breakdown