How much VRAM does Qwen 2.5 VL 72B need?

Qwen 2.5 VL 72B (72B parameters) requires approximately 62.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 VL 72B?

The recommended quantization for Qwen 2.5 VL 72B is Q4_K_M, which balances quality and memory efficiency.

Can it run?

No, Qwen 2.5 VL 72B requires more memory than RTX PRO 5000 Blackwell 48GB provides.

FWon't run

Too heavy

Using Q4_K_M in vLLM

Capabilities:

Fit status

Too heavy

Decode

22.0 tok/s

TTFT

8787 ms

Safe context

12K

Memory

62.4 GB / 48.0 GB

Weights43.9 GB

KV Cache11.3 GB

Runtime2.4 GB

Headroom4.8 GB

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	F	Too heavy	25.7 tok/s	10955 ms	21K
Chat	D	Very compromised (needs ~6.8 GB host RAM)	22.5 tok/s	4686 ms	7K
Coding	F	Too heavy	22.0 tok/s	8787 ms	12K
RAG	F	Too heavy	25.7 tok/s	13694 ms	21K
Reasoning	F	Too heavy	25.7 tok/s	8901 ms	12K

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on RTX PRO 5000 Blackwell 48GB (48.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	C42
Q3_K_SBest for your GPU	3	35.3 GB	Low	C44

Upgrade options

MacBook Pro M3 Max 128GBBudget pick

C5.5 tok/s decode

~$2,499 MSRP

MacBook Pro M4 Max 96GBBest value

C7.8 tok/s decode

~$2,499 MSRP

NVIDIA GH200 96GBBiggest leap