How much VRAM does Qwen 2.5 VL 72B need?

Qwen 2.5 VL 72B (72B parameters) requires approximately 62.8 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 VL 72B?

The recommended quantization for Qwen 2.5 VL 72B is Q4_K_M, which balances quality and memory efficiency.

Can it run?

No, Qwen 2.5 VL 72B requires more memory than MacBook Pro M4 Max 48GB provides.

FWon't run

Too heavy

Using Q4_K_M in vLLM

Capabilities:

Fit status

Too heavy

Decode

8.1 tok/s

TTFT

23959 ms

Safe context

Memory

62.8 GB / 34.6 GB

Weights43.9 GB

KV Cache11.3 GB

Runtime2.4 GB

Headroom5.2 GB

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	F	Too heavy	7.8 tok/s	35955 ms	15K
Chat	F	Too heavy	7.8 tok/s	13483 ms	5K
Coding	F	Too heavy	8.1 tok/s	23959 ms	9K
RAG	F	Too heavy	7.8 tok/s	44944 ms	15K
Reasoning	F	Too heavy	7.8 tok/s	29214 ms	9K

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on MacBook Pro M4 Max 48GB (34.6 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	C44
Q3_K_S	3	35.3 GB	Low	F0
NVFP4	4

Upgrade options

MacBook Pro M3 Max 128GBBudget pick

C5.5 tok/s decode

~$2,499 MSRP

MacBook Pro M4 Max 96GBBest value

C7.8 tok/s decode

~$2,499 MSRP