How much VRAM does Qwen 2.5 VL 72B need?

Qwen 2.5 VL 72B (72B parameters) requires approximately 71.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 VL 72B?

The recommended quantization for Qwen 2.5 VL 72B is Q4_K_M, which balances quality and memory efficiency.

Can it run?

Yes, MacBook Pro M3 Max 128GB can run Qwen 2.5 VL 72B with a C grade (Runs well). Expected decode speed: 5.9 tok/s.

CUsable

Runs well

Using Q4_K_M in vLLM

Capabilities:

Fit status

Runs well

Decode

5.9 tok/s

TTFT

32704 ms

Safe context

21K

Memory

71.4 GB / 92.2 GB

Weights43.9 GB

KV Cache11.3 GB

Runtime2.4 GB

Headroom13.8 GB

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Tight fit	5.5 tok/s	51533 ms	33K
Chat	C	Runs well	5.5 tok/s	19325 ms	11K
Coding	C	Runs well	5.9 tok/s	32704 ms	21K
RAG	C	Tight fit	5.5 tok/s	64416 ms	33K
Reasoning	C	Runs well	5.5 tok/s	41870 ms	21K

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on MacBook Pro M3 Max 128GB (92.2 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	D36
Q3_K_S	3	35.3 GB	Low	D38
NVFP4	4

Ollama

ollama run qwen-2.5-vl-72b

HuggingFace

huggingface-cli download qwen-2.5-vl-72b

Upgrade options

AMD Instinct MI350X 288GBBudget pick

C133 tok/s decode

~$8,000 MSRP

AMD Instinct MI250X 128GBBest value

C56.8 tok/s decode

~$15,000 MSRP

NVIDIA GH200 96GBBiggest leap