How much VRAM does Qwen 2.5 VL 72B need?

Qwen 2.5 VL 72B (72B parameters) requires approximately 71.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 VL 72B?

The recommended quantization for Qwen 2.5 VL 72B is Q4_K_M, which balances quality and memory efficiency.

Can it run?

Yes, Mac Studio M2 Ultra 128GB can run Qwen 2.5 VL 72B with a C grade (Runs well). Expected decode speed: 11.8 tok/s.

CUsable

Runs well

Using Q4_K_M in vLLM

Capabilities:

Fit status

Runs well

Decode

11.8 tok/s

TTFT

16352 ms

Safe context

21K

Memory

71.4 GB / 92.2 GB

Weights43.9 GB

KV Cache11.3 GB

Runtime2.4 GB

Headroom13.8 GB

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Tight fit	10.6 tok/s	26655 ms	33K
Chat	C	Runs well	10.6 tok/s	9996 ms	11K
Coding	C	Runs well	11.8 tok/s	16352 ms	21K
RAG	C	Tight fit	10.6 tok/s	33319 ms	33K
Reasoning	C	Runs well	10.6 tok/s	21657 ms	21K

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on Mac Studio M2 Ultra 128GB (92.2 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	D36
Q3_K_S	3	35.3 GB	Low	D38
NVFP4	4

Ollama

ollama run qwen-2.5-vl-72b

HuggingFace

huggingface-cli download qwen-2.5-vl-72b

Upgrade options

AMD Instinct MI250X 128GBBudget pick

C56.8 tok/s decode

~$15,000 MSRP

AMD Instinct MI300X 192GBBest value

C94.1 tok/s decode

~$15,000 MSRP

NVIDIA GH200 96GBBiggest leap