How much VRAM does Qwen 2.5 VL 72B need?

Qwen 2.5 VL 72B (72B parameters) requires approximately 64.5 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 VL 72B?

The recommended quantization for Qwen 2.5 VL 72B is Q4_K_M, which balances quality and memory efficiency.

Can it run?

No, Qwen 2.5 VL 72B requires more memory than Mac Studio M1 Ultra 64GB provides.

FWon't run

Too heavy

Using Q4_K_M in vLLM

Capabilities:

Fit status

Too heavy

Decode

11.8 tok/s

TTFT

16352 ms

Safe context

11K

Memory

64.5 GB / 46.1 GB

Weights43.9 GB

KV Cache11.3 GB

Runtime2.4 GB

Headroom6.9 GB

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	F	Too heavy	10.0 tok/s	28109 ms	19K
Chat	F	Too heavy	10.0 tok/s	10541 ms	6K
Coding	F	Too heavy	11.8 tok/s	16352 ms	11K
RAG	F	Too heavy	10.0 tok/s	35136 ms	19K
Reasoning	F	Too heavy	10.0 tok/s	22838 ms	11K

How Qwen 2.5 VL 72B (72B params) fits at each quantization level on Mac Studio M1 Ultra 64GB (46.1 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_KBest for your GPU	2	28.1 GB	Low	C42
Q3_K_S	3	35.3 GB	Low	C44

Upgrade options

MacBook Pro M3 Max 128GBBudget pick

C5.5 tok/s decode

~$2,499 MSRP

MacBook Pro M4 Max 96GBBest value

C7.8 tok/s decode

~$2,499 MSRP