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All estimates are approximations based on mathematical models and public specifications. Actual performance may vary. Do not make purchasing decisions based solely on these estimates.

Data sourced from Hugging Face, Ollama, and official model documentation. Model names and logos are trademarks of their respective owners.

© 2026 Will It Run AI — Fase Consulting Ibiza, S.L. (NIF: B57969656)

Home/Qwen 2.5 72B/on Mac Studio M2 Ultra 64GB

Can it run?

Can Mac Studio M2 Ultra 64GB run Qwen 2.5 72B?

FWon't run

Too heavy

Using Q4_K_M in Ollama

Capabilities:

Fit status

Too heavy

Decode

10.6 tok/s

TTFT

18325 ms

Safe context

12K

Memory

63.3 GB / 46.1 GB

Memory breakdown

Weights43.9 GB
KV Cache11.3 GB
Runtime1.2 GB
Headroom6.9 GB

Performance by workload

WorkloadGradeFitDecodeTTFTContext
Agentic CodingFToo heavy10.6 tok/s26655 ms20K
ChatFToo heavy10.6 tok/s9996 ms6K
CodingFToo heavy10.6 tok/s18325 ms12K
RAGFToo heavy10.6 tok/s33319 ms20K
ReasoningFToo heavy10.6 tok/s21657 ms12K

Quantization options

How Qwen 2.5 72B (72B params) fits at each quantization level on Mac Studio M2 Ultra 64GB (46.1 GB usable).

QuantBitsVRAMQualityFit
Q2_KBest for your GPU
2
28.1 GB
LowC43
Q3_K_S
3
35.3 GB
LowC45
NVFP4
4
40.3 GB
MediumC45
Q4_K_M
4
43.9 GB
MediumC45
Q5_K_M
5
51.8 GB
HighF0
Q6_K
6
59.0 GB
HighF0
Q8_0
8
77.0 GB
Very HighF0
F16
16
147.6 GB
MaximumF0

Upgrade options

Hardware that runs Qwen 2.5 72B well

AppleMacBook Pro M3 Max 128GBBudget pick
C5.5 tok/s decode

~$2,499 MSRP

AppleMacBook Pro M4 Max 96GBBest value
C7.8 tok/s decode

~$2,499 MSRP

AppleMac Studio M2 Ultra 128GBApple upgrade
C10.6 tok/s decode

~$3,999 MSRP

NVIDIANVIDIA GH200 96GBBiggest leap
B73.8 tok/s decode

 

See all results for Mac Studio M2 Ultra 64GBSee all hardware for Qwen 2.5 72B