Question 1

Can AMD Instinct MI325X 256GB run Qwen 2.5 72B?

Accepted Answer

Yes, AMD Instinct MI325X 256GB can run Qwen 2.5 72B with a C grade (Runs well). Expected decode speed: 98.4 tok/s.

Question 2

How much VRAM does Qwen 2.5 72B need?

Accepted Answer

Qwen 2.5 72B (72B parameters) requires approximately 82.0 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen 2.5 72B?

Accepted Answer

The recommended quantization for Qwen 2.5 72B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	98.4 tok/s	2863 ms	88K
Chat	C	Runs well	98.4 tok/s	1074 ms	27K
Coding	C	Runs well	98.4 tok/s	1968 ms	50K
RAG	C	Runs well	98.4 tok/s	3579 ms	88K
Reasoning	C	Runs well	98.4 tok/s	2326 ms	50K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	D32
Q3_K_S	3	35.3 GB	Low	D32
NVFP4	4

Can AMD Instinct MI325X 256GB run Qwen 2.5 72B?

Memory breakdown