Question 1

Can NVIDIA H200 PCIe 141GB run Qwen 2.5 72B?

Accepted Answer

Yes, NVIDIA H200 PCIe 141GB can run Qwen 2.5 72B with a C grade (Runs well). Expected decode speed: 78.7 tok/s.

Question 2

How much VRAM does Qwen 2.5 72B need?

Accepted Answer

Qwen 2.5 72B (72B parameters) requires approximately 70.5 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen 2.5 72B?

Accepted Answer

The recommended quantization for Qwen 2.5 72B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	91.8 tok/s	3067 ms	55K
Chat	C	Runs well	91.8 tok/s	1150 ms	17K
Coding	C	Runs well	78.7 tok/s	2460 ms	32K
RAG	C	Runs well	91.8 tok/s	3834 ms	55K
Reasoning	C	Runs well	91.8 tok/s	2492 ms	32K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	D34
Q3_K_S	3	35.3 GB	Low	D35
NVFP4	4

Can NVIDIA H200 PCIe 141GB run Qwen 2.5 72B?

Memory breakdown