Question 1

Can H100 NVL 188GB run Qwen 2.5 72B?

Accepted Answer

Yes, H100 NVL 188GB can run Qwen 2.5 72B with a C grade (Runs well). Expected decode speed: 143.9 tok/s.

Question 2

How much VRAM does Qwen 2.5 72B need?

Accepted Answer

Qwen 2.5 72B (72B parameters) requires approximately 75.2 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen 2.5 72B?

Accepted Answer

The recommended quantization for Qwen 2.5 72B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	143.9 tok/s	1958 ms	70K
Chat	C	Runs well	127.9 tok/s	950 ms	22K
Coding	C	Runs well	143.9 tok/s	1346 ms	40K
RAG	C	Runs well	143.9 tok/s	2447 ms	70K
Reasoning	C	Runs well	143.9 tok/s	1591 ms	40K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	D33
Q3_K_S	3	35.3 GB	Low	D34
NVFP4	4

Can H100 NVL 188GB run Qwen 2.5 72B?

Memory breakdown