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All estimates are approximations based on mathematical models and public specifications. Actual performance may vary. Do not make purchasing decisions based solely on these estimates.

Data sourced from Hugging Face, Ollama, and official model documentation. Model names and logos are trademarks of their respective owners.

© 2026 Will It Run AI — Fase Consulting Ibiza, S.L. (NIF: B57969656)

Home/Mixtral 8x22B/on MacBook Pro M4 Pro 64GB

Can it run?

Can MacBook Pro M4 Pro 64GB run Mixtral 8x22B?

FWon't run

Too heavy

Using Q4_K_M in llama.cpp

Capabilities:

Fit status

Too heavy

Decode

4.7 tok/s

TTFT

41292 ms

Safe context

7K

Memory

99.9 GB / 46.1 GB

Memory breakdown

Weights86.0 GB
KV Cache6.1 GB
Runtime0.9 GB
Headroom6.9 GB

Performance by workload

WorkloadGradeFitDecodeTTFTContext
Agentic CodingFToo heavy4.7 tok/s60062 ms14K
ChatFToo heavy4.7 tok/s22523 ms4K
CodingFToo heavy4.7 tok/s41292 ms7K
RAGFToo heavy4.7 tok/s75077 ms14K
ReasoningFToo heavy4.7 tok/s48800 ms7K

Quantization options

How Mixtral 8x22B (141B params) fits at each quantization level on MacBook Pro M4 Pro 64GB (46.1 GB usable).

QuantBitsVRAMQualityFit
Q2_K
2
55.0 GB
LowF0
Q3_K_S
3
69.1 GB
LowF0
NVFP4
4
79.0 GB
MediumF0
Q4_K_M
4
86.0 GB
MediumF0
Q5_K_M
5
101.5 GB
HighF0
Q6_K
6
115.6 GB
HighF0
Q8_0
8
150.9 GB
Very HighF0
F16
16
289.0 GB
MaximumF0

Upgrade options

Hardware that runs Mixtral 8x22B well

AppleMacBook Pro M3 Max 128GBBest value
D5.1 tok/s decode

~$2,499 MSRP

AMDAMD Instinct MI350X 288GBBudget pick
C130.3 tok/s decode

~$8,000 MSRP

NVIDIANVIDIA H200 141GBBiggest leap
B89.9 tok/s decode

~$30,000 MSRP

AppleMac Studio M3 Ultra 256GBApple upgrade
C12.4 tok/s decode

 

See all results for MacBook Pro M4 Pro 64GBSee all hardware for Mixtral 8x22B