Question 1

Can AMD Instinct MI350X 288GB run Mixtral 8x22B?

Accepted Answer

Yes, AMD Instinct MI350X 288GB can run Mixtral 8x22B with a C grade (Runs well). Expected decode speed: 128.5 tok/s.

Question 2

How much VRAM does Mixtral 8x22B need?

Accepted Answer

Mixtral 8x22B (141B parameters) requires approximately 121.8 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Mixtral 8x22B?

Accepted Answer

The recommended quantization for Mixtral 8x22B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	128.5 tok/s	2192 ms	66K
Chat	C	Runs well	128.5 tok/s	822 ms	19K
Coding	C	Runs well	128.5 tok/s	1507 ms	38K
RAG	C	Runs well	128.5 tok/s	2740 ms	66K
Reasoning	C	Runs well	128.5 tok/s	1781 ms	38K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	55.0 GB	Low	D34
Q3_K_S	3	69.1 GB	Low	D35
NVFP4	4

Can AMD Instinct MI350X 288GB run Mixtral 8x22B?

Memory breakdown