Question 1

Can AMD Instinct MI300X 192GB run Mixtral 8x22B?

Accepted Answer

Yes, AMD Instinct MI300X 192GB can run Mixtral 8x22B with a C grade (Runs well). Expected decode speed: 85.1 tok/s.

Question 2

How much VRAM does Mixtral 8x22B need?

Accepted Answer

Mixtral 8x22B (141B parameters) requires approximately 112.2 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Mixtral 8x22B?

Accepted Answer

The recommended quantization for Mixtral 8x22B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	B	Runs well	92.2 tok/s	3054 ms	52K
Chat	C	Runs well	92.2 tok/s	1145 ms	14K
Coding	C	Runs well	85.1 tok/s	2275 ms	27K
RAG	B	Runs well	92.2 tok/s	3818 ms	52K
Reasoning	C	Runs well	92.2 tok/s	2481 ms	27K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	55.0 GB	Low	D36
Q3_K_S	3	69.1 GB	Low	D37
NVFP4	4

Can AMD Instinct MI300X 192GB run Mixtral 8x22B?

Memory breakdown