Question 1

Can NVIDIA H200 141GB run Mixtral 8x22B?

Accepted Answer

Yes, NVIDIA H200 141GB can run Mixtral 8x22B with a B grade (Runs well). Expected decode speed: 77.1 tok/s.

Question 2

How much VRAM does Mixtral 8x22B need?

Accepted Answer

Mixtral 8x22B (141B parameters) requires approximately 107.1 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Mixtral 8x22B?

Accepted Answer

The recommended quantization for Mixtral 8x22B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	B	Runs well	89.9 tok/s	3131 ms	40K
Chat	B	Runs well	89.9 tok/s	1174 ms	11K
Coding	B	Runs well	77.1 tok/s	2512 ms	21K
RAG	B	Runs well	89.9 tok/s	3914 ms	40K
Reasoning	B	Runs well	89.9 tok/s	2544 ms	21K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	55.0 GB	Low	D38
Q3_K_S	3	69.1 GB	Low	C40
NVFP4	4

Can NVIDIA H200 141GB run Mixtral 8x22B?

Memory breakdown