Question 1

Can AMD Instinct MI250 128GB run Mistral Large 3?

Accepted Answer

No, Mistral Large 3 requires more memory than AMD Instinct MI250 128GB provides.

Question 2

How much VRAM does Mistral Large 3 need?

Accepted Answer

Mistral Large 3 (675B parameters) requires approximately 433.4 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Mistral Large 3?

Accepted Answer

The recommended quantization for Mistral Large 3 is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	F	Too heavy	15.2 tok/s	18575 ms	9K
Chat	F	Too heavy	15.2 tok/s	6966 ms	4K
Coding	F	Too heavy	15.2 tok/s	12770 ms	5K
RAG	F	Too heavy	16.1 tok/s	21929 ms	9K
Reasoning	F	Too heavy	15.2 tok/s	15092 ms	5K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	263.3 GB	Low	F0
Q3_K_S	3	330.8 GB	Low	F0
NVFP4	4

Can AMD Instinct MI250 128GB run Mistral Large 3?

Memory breakdown