Question 1

Can AMD Instinct MI325X 256GB run Llama 3.3 70B?

Accepted Answer

Yes, AMD Instinct MI325X 256GB can run Llama 3.3 70B with a C grade (Runs well). Expected decode speed: 101.2 tok/s.

Question 2

How much VRAM does Llama 3.3 70B need?

Accepted Answer

Llama 3.3 70B (70B parameters) requires approximately 80.4 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Llama 3.3 70B?

Accepted Answer

The recommended quantization for Llama 3.3 70B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	101.2 tok/s	2783 ms	90K
Chat	C	Runs well	101.2 tok/s	1044 ms	27K
Coding	C	Runs well	101.2 tok/s	1914 ms	51K
RAG	C	Runs well	101.2 tok/s	3479 ms	90K
Reasoning	C	Runs well	101.2 tok/s	2262 ms	51K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	D32
Q3_K_S	3	34.3 GB	Low	D32
NVFP4	4

Can AMD Instinct MI325X 256GB run Llama 3.3 70B?

Memory breakdown