Question 1

Can AMD Instinct MI250X 128GB run Qwen3.5 397B A17B?

Accepted Answer

No, Qwen3.5 397B A17B requires more memory than AMD Instinct MI250X 128GB provides.

Question 2

How much VRAM does Qwen3.5 397B A17B need?

Accepted Answer

Qwen3.5 397B A17B (397B parameters) requires approximately 318.2 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 397B A17B?

Accepted Answer

The recommended quantization for Qwen3.5 397B A17B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	F	Too heavy	10.3 tok/s	27322 ms	11K
Chat	F	Too heavy	10.3 tok/s	10246 ms	4K
Coding	F	Too heavy	10.3 tok/s	18784 ms	6K
RAG	F	Too heavy	10.3 tok/s	34152 ms	11K
Reasoning	F	Too heavy	10.3 tok/s	22199 ms	6K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	154.8 GB	Low	F0
Q3_K_S	3	194.5 GB	Low	F0
NVFP4	4

Can AMD Instinct MI250X 128GB run Qwen3.5 397B A17B?

Memory breakdown