Question 1

Can AMD Instinct MI325X 256GB run Qwen3.5 35B A3B?

Accepted Answer

Yes, AMD Instinct MI325X 256GB can run Qwen3.5 35B A3B with a C grade (Runs well). Expected decode speed: 205.2 tok/s.

Question 2

How much VRAM does Qwen3.5 35B A3B need?

Accepted Answer

Qwen3.5 35B A3B (35B parameters) requires approximately 53.6 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 35B A3B?

Accepted Answer

The recommended quantization for Qwen3.5 35B A3B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	205.2 tok/s	1373 ms	139K
Chat	C	Runs well	205.2 tok/s	515 ms	40K
Coding	C	Runs well	205.2 tok/s	944 ms	76K
RAG	C	Runs well	205.2 tok/s	1716 ms	139K
Reasoning	C	Runs well	202.3 tok/s	1131 ms	76K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	13.7 GB	Low	D31
Q3_K_S	3	17.2 GB	Low	D31
NVFP4	4

Can AMD Instinct MI325X 256GB run Qwen3.5 35B A3B?

Memory breakdown