Question 1

Can AMD Instinct MI350X 288GB run Qwen3.5 27B?

Accepted Answer

Yes, AMD Instinct MI350X 288GB can run Qwen3.5 27B with a C grade (Runs well). Expected decode speed: 349.7 tok/s.

Question 2

How much VRAM does Qwen3.5 27B need?

Accepted Answer

Qwen3.5 27B (27B parameters) requires approximately 50.7 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 27B?

Accepted Answer

The recommended quantization for Qwen3.5 27B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	354.6 tok/s	794 ms	168K
Chat	C	Runs well	354.6 tok/s	350 ms	47K
Coding	C	Runs well	349.7 tok/s	653 ms	91K
RAG	C	Runs well	354.6 tok/s	993 ms	168K
Reasoning	C	Runs well	354.6 tok/s	645 ms	91K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	D30
Q3_K_S	3	13.2 GB	Low	D31
NVFP4	4

Can AMD Instinct MI350X 288GB run Qwen3.5 27B?

Memory breakdown