Question 1

Can AMD Instinct MI250X 128GB run Qwen3.5 27B?

Accepted Answer

Yes, AMD Instinct MI250X 128GB can run Qwen3.5 27B with a C grade (Runs well). Expected decode speed: 139.9 tok/s.

Question 2

How much VRAM does Qwen3.5 27B need?

Accepted Answer

Qwen3.5 27B (27B parameters) requires approximately 34.7 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 27B?

Accepted Answer

The recommended quantization for Qwen3.5 27B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	139.9 tok/s	2013 ms	105K
Chat	C	Runs well	139.9 tok/s	755 ms	31K
Coding	C	Runs well	139.9 tok/s	1384 ms	59K
RAG	C	Runs well	139.9 tok/s	2516 ms	105K
Reasoning	C	Runs well	139.9 tok/s	1636 ms	59K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	D31
Q3_K_S	3	13.2 GB	Low	D32
NVFP4	4

Can AMD Instinct MI250X 128GB run Qwen3.5 27B?

Memory breakdown