Question 1

Can AMD Instinct MI325X 256GB run Qwen3.5 122B A10B?

Accepted Answer

Yes, AMD Instinct MI325X 256GB can run Qwen3.5 122B A10B with a C grade (Runs well). Expected decode speed: 68.1 tok/s.

Question 2

How much VRAM does Qwen3.5 122B A10B need?

Accepted Answer

Qwen3.5 122B A10B (122B parameters) requires approximately 105.6 GB of memory with Q3_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 122B A10B?

Accepted Answer

The recommended quantization for Qwen3.5 122B A10B is Q3_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	68.1 tok/s	4133 ms	66K
Chat	C	Runs well	68.1 tok/s	1550 ms	21K
Coding	C	Runs well	68.1 tok/s	2841 ms	39K
RAG	C	Runs well	68.1 tok/s	5166 ms	66K
Reasoning	C	Runs well	67.2 tok/s	3489 ms	39K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	47.6 GB	Low	D33
Q3_K_S	3	59.8 GB	Low	D35
NVFP4	4

Can AMD Instinct MI325X 256GB run Qwen3.5 122B A10B?

Memory breakdown