Question 1

Can AMD Instinct MI300A 128GB run Qwen3.5 122B A10B?

Accepted Answer

Yes, AMD Instinct MI300A 128GB can run Qwen3.5 122B A10B with a B grade (Runs well). Expected decode speed: 57.7 tok/s.

Question 2

How much VRAM does Qwen3.5 122B A10B need?

Accepted Answer

Qwen3.5 122B A10B (122B parameters) requires approximately 92.8 GB of memory with Q3_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 122B A10B?

Accepted Answer

The recommended quantization for Qwen3.5 122B A10B is Q3_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Tight fit	57.7 tok/s	4879 ms	37K
Chat	C	Runs well	57.7 tok/s	1830 ms	12K
Coding	B	Runs well	57.7 tok/s	3354 ms	22K
RAG	C	Tight fit	59.4 tok/s	5929 ms	37K
Reasoning	B	Runs well	57.7 tok/s	3964 ms	22K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	47.6 GB	Low	D37
Q3_K_S	3	59.8 GB	Low	D40
NVFP4	4

Can AMD Instinct MI300A 128GB run Qwen3.5 122B A10B?

Memory breakdown