Question 1

Can AMD Instinct MI350X 288GB run Qwen3.5 35B A3B?

Accepted Answer

Yes, AMD Instinct MI350X 288GB can run Qwen3.5 35B A3B with a C grade (Runs well). Expected decode speed: 273.5 tok/s.

Question 2

How much VRAM does Qwen3.5 35B A3B need?

Accepted Answer

Qwen3.5 35B A3B (35B parameters) requires approximately 56.8 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 35B A3B?

Accepted Answer

The recommended quantization for Qwen3.5 35B A3B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	273.5 tok/s	1029 ms	148K
Chat	C	Runs well	273.5 tok/s	386 ms	43K
Coding	C	Runs well	273.5 tok/s	708 ms	81K
RAG	C	Runs well	273.5 tok/s	1287 ms	148K
Reasoning	C	Runs well	273.5 tok/s	836 ms	81K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	13.7 GB	Low	D30
Q3_K_S	3	17.2 GB	Low	D31
NVFP4	4

Can AMD Instinct MI350X 288GB run Qwen3.5 35B A3B?

Memory breakdown