Question 1

Can AMD Instinct MI250 128GB run Qwen3.5 35B A3B?

Accepted Answer

Yes, AMD Instinct MI250 128GB can run Qwen3.5 35B A3B with a C grade (Runs well). Expected decode speed: 107.9 tok/s.

Question 2

How much VRAM does Qwen3.5 35B A3B need?

Accepted Answer

Qwen3.5 35B A3B (35B parameters) requires approximately 40.8 GB of memory with Q4_K_M quantization.

Question 3

What is the best quantization for Qwen3.5 35B A3B?

Accepted Answer

The recommended quantization for Qwen3.5 35B A3B is Q4_K_M, which balances quality and memory efficiency.

Workload	Grade	Fit	Decode	TTFT	Context
Agentic Coding	C	Runs well	101.9 tok/s	2763 ms	88K
Chat	C	Runs well	101.9 tok/s	1036 ms	27K
Coding	C	Runs well	107.9 tok/s	1794 ms	50K
RAG	C	Runs well	101.9 tok/s	3454 ms	88K
Reasoning	C	Runs well	101.9 tok/s	2245 ms	50K

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	13.7 GB	Low	D32
Q3_K_S	3	17.2 GB	Low	D32
NVFP4	4

Can AMD Instinct MI250 128GB run Qwen3.5 35B A3B?

Memory breakdown